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The Effect Score was subdivided into a metric of increasing responses and decreasing responses (ES_increase and ES_decrease)
When the receptor is engaged, it kicks off intracellular signaling cascades that drive both protein-building activity and cell proliferation
Shimizu S, Narita M, Tsujimoto Y, Tsujimoto Y (1999) Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
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